December 4, 2001
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Smallpox Vaccine: Side Effects Raise Concern
Half Want Shot, Half Dubious

Analysis
By Gary Langer

ABCNEWS.com

Dec. 4 — Half of Americans say they'd get a smallpox shot if one were available, but the other half are dubious, given the vaccine's potential side effects — the same reason the Centers for Disease Control doesn't plan mass vaccinations.


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Fifty percent in this ABCNEWS poll said they'd get a smallpox shot; 41 percent say they'd decline and the rest are unsure. Respondents were given pro and con arguments — on one hand, protection against possible bioterrorism; on the other, the risk of the vaccine itself.


Get a smallpox shot?
YES NO
All 50% 41
     
Age 18-34 43 51
Age 55-64 58 33
     
Southerners 56 36
Midwesterners 43 48
     
Democrats 56 37
Republicans 52 39
Independents 44 50

Health experts say the vaccine could kill one in 500,000 people and make one in 150,000 seriously ill. As the poll posed it, "Some people say all Americans should be vaccinated against smallpox to protect them in case terrorists try to spread the disease. Others say the chance that terrorists could get ahold of smallpox is too slight to justify the risk of the vaccine itself."

Groups most likely to say they'd decline the shot include young adults (under age 35) and political independents. Those most likely to say they'd get a smallpox shot include middle-aged people, Southerners and Democrats.

Feds to Boost Vaccine Stocks

Federal authorities last week said they would stockpile the vaccine, announcing a $428 million contract to buy 155 million doses, but would not undertake "indiscriminate mass vaccination campaigns."

The CDC's Smallpox Response Plan says "ring vaccination" — identifying and vaccinating people with possible exposure — is preferable, given factors including the vaccine's risks. It works even if administered a few days after exposure.

"The reason not to just immunize everyone has to do with the reactogenicity of the vaccine," says John D. Clements, an immunologist at Tulane University School of Medicine. "If everyone were immunized, based on our previous experience with this vaccine, you would expect to see 300 to 600 deaths and approximately 2,000 cases of encephalitis. This vaccine has more potentially deadly side effects than any vaccine currently in use. That's why the decision was made to stop using it."

Methodology

This ABCNEWS.com survey was conducted by telephone November 28-Dec. 2, 2001, among a random national sample of 1,022 adults. The results have a three-point error margin. Sampling, data collection and tabulation by TNS Intersearch of Horsham, Pa.

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